This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Trial Assessed Personalized Approach to Reducing Older Adults’ Risks for Fall-Related Injuries
Falls are the leading cause of injury-related death among older Americans and lead to 3 million emergency department visits every year. A paper in the New England Journal of Medicine highlights findings from the PCORI- and National Institutes of Health-funded STRIDE Study, a large-scale trial that assessed a personalized approach to reducing older adults’ risks for fall-related injuries in typical primary care settings. The study found that having nurses tailor and administer fall-prevention plans for older adults at high risk resulted in about an 8 percent to 10 percent reduction in serious fall injuries, but this effect was not statistically significant. The paper discusses potential barriers to care and other factors that could account for why a more significant reduction in serious fall injuries was not seen when risk-reduction strategies shown to be effective in previous studies were deployed this way in real-world circumstances and settings.
Study Analyzes Treatments for Uterine Fibroids
Uterine fibroids—growths in the uterus that may cause heavy menstrual bleeding, pain, and feelings of abdominal pressure—are common health problems in women of childbearing age. They occur more frequently in African-American women than in women of other races. The PCORI-funded COMPARE-UF study set up a registry of women treated for fibroids to compare multiple outcomes of different treatment options. One study done using information from COMPARE-UF compared two types of uterine fibroid removal: hysterectomy, which is the removal of the uterus, and myomectomy, which is removal of only the fibroids. As published in Fertility and Sterility, both treatments increased quality of life one year after treatment. Depending on whether fibroid removal was done using abdominal or minimally invasive surgery, there were slight or no differences in quality of life.