MOTS Trial: Comparing Ways to Manage Symptoms for Patients Who Have Chronic Migraine and Frequent Medication Use
About Us
- About PCORI
- The PCORI Strategic Plan
- Governance
- Evaluating Our Work
- PCORI's Advisory Panels
- Procurement Opportunities
-
Provide Input
- Draft Key Questions: Systematic Review of Audio Care for the Management of Mental Health and Chronic Conditions (2023)
- Patient-Centered Economic Outcomes Landscape (2023-2024)
-
Past Opportunities to Provide Input
- Proposed New Methodology Standards for Usual Care as a Comparator (2023)
- Stakeholder Views on Components of 'Patient-Centered Value' in Health and Health Care (2023)
- PCORI's Proposed Research Agenda (2021-2022)
- Proposed National Priorities for Health (2021)
- Proposed Principles for the Consideration of the Full Range of Outcomes Data in PCORI-Funded Research (2020)
- Proposed New PCORI Methodology Standards (2018)
- Data Access and Data Sharing Policy: Public Comment (2017)
- Proposed New PCORI Methodology Standards (2017)
-
Comment on the Proposed New and Revised PCORI Methodology Standards (2016)
- 1. Standards for Formulating Research Questions
- 10: Standards for Studies of Diagnostic Tests
- 12. Standards on Research Designs Using Clusters
- 13: General Comments on the Proposed Revisions to the PCORI Methodology Standards
- 2: Standards Associated with Patient-Centeredness
- 3: Standards for Data Integrity and Rigorous Analysis
- 4: Standards for Preventing and Handling Missing Data
- 5: Standards for Heterogeneity of Treatment Effects
- 6: Standards for Data Registries
- 7: Standards for Data Networks as Research-Facilitating Structures
- 8. Standards for Causal Inference Methods
- 9. Standards for Adaptive Trial Designs
- Peer-Review Process Comments (2014)
- Draft Methodology Report Public Comment Period (2012)
- Leadership
Many people with chronic migraines use medication more often than recommended. This overuse can have the undesired effect of more migraines and headaches and other serious side effects.
Image
The PCORI-funded MOTS (Medication Overuse Treatment Strategy) Trial compared two ways to treat adult patients who have chronic migraine and medication overuse. It found that not switching or limiting medication wasn’t worse than switching medication, according to results published in Neurology.
But the study also found that patients who stopped the overused medicine took it to treat symptoms less often than patients who continued it. They were also less likely to overuse migraine medicines.
The research team, led by Todd J. Schwedt, MD, MS, of Mayo Clinic Arizona, assigned patients by chance to one of the two treatment approaches. They surveyed patients at the start of the study and again 9–12 weeks later. Patients kept a diary for weeks 1–12 and other 4-week periods over one year. They recorded how often they had headaches, how intense they were, and how long they lasted. Patients also recorded whether they used medicine to treat symptoms.
Posted: March 11, 2022
Tags
Recent Posts
What's Happening at PCORI?
The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.
Image
