PCORnet®, The National Patient-Centered Clinical Research Network

The Patient-Centered Outcomes Research Institute (PCORI) is committed to advancing the capacity of PCORnet®, The National Patient-Centered Clinical Research Network, to fulfill the need for stakeholder-prioritized rapid-cycle research studies and projects. The PCORI Board of Governors approved funding for rapid-cycle research studies and projects using PCORnet’s infrastructure to support stakeholder-prioritized rapid evidence generation. Research studies and projects that use PCORnet are funded to assess the feasibility of conducting future stakeholder-prioritized research and to complete small, rapid, observational research studies that address stakeholder-prioritized research questions.

The Projects

Descriptive Analytics

Cancer: This rapid-cycle descriptive analysis project aims to learn about the patterns of use of molecular biomarkers (tumor or germline) and associated targeted cancer therapies for patients with new-onset solid tumors (all single primary invasive solid tumors) cared for in a variety of community and academic care settings.

Diabetes: This rapid-cycle descriptive analysis project is focused on describing and validating PCORnet data on the use of several major classes of glucose-lowering medications for type 2 diabetes.

Opioid Surveillance: This rapid-cycle descriptive analysis project aims to demonstrate PCORnet’s capacity to create a more robust Opioid Surveillance Data Set and address current gaps in timely access to clinical data necessary for surveillance, prevention, and intervention.

Patient-Reported Outcomes Measurement (PROM): This rapid-cycle descriptive analysis project provides an opportunity for demonstrating the utility and value of collecting patient-reported outcomes measures (PROMs) during routine care in a standardized format for use in research analyses conducted within PCORnet.

PCSK9 Inhibitors: The purpose of this rapid-cycle descriptive analysis project is to learn about the trends and prevalence of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a class of medication therapies used to lower LDL cholesterol, or bad cholesterol, and treat hyperlipidemia.

Observational Studies

Hepatitis C: This 12-month rapid-cycle retrospective observational research study conducted by investigators using PCORnet infrastructure aims to evaluate whether patients with hepatitis C virus (HCV) who are prescribed newer direct-acting antiviral (DAA) medications experience higher rates of adverse events than HCV patients who are untreated.


Posted: January 5, 2018; Updated: May 30, 2019

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