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Estrogen Use and the Risk for Blood Clots and Strokes Among Transgender Women (Evidence Update for Transgender Women)

Download this Evidence Update for Transgender Women

Many transgender women pursue medical transition with hormone therapy to help align their bodies with their female gender identity. Findings from this PCORI-funded study, which showed increased cardiovascular risks from estrogen use in transgender women, may help transgender women and their clinicians plan for ongoing health care.

The study found that transgender women taking estrogen for gender affirmation had a higher risk of stroke and blood clots than nontransgender women and nontransgender men. The highest risk differences were found several years after starting estrogen.

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