The objective of this study was to evaluate the effectiveness of medical therapy alone versus patent foramen ovale (PFO) closure plus medical therapy to prevent recurrent stroke, overall and across patient subgroups, in patients with PFO-associated cerebral ischemic events.

Project page: Evaluating Therapies to Prevent Future Stroke in Patients with Patent Foramen Ovale-Related Strokes -- The SCOPE Study
Principal Investigator: David M. Kent, MD, MS
Organization: Tufts Medical Center Inc.
Original project title: The Systematic , Collaborative, PFO Closure Evaluation (SCOPE)

To cite this document, please use: Kent DM, Saver JL, Kasner SE, et al. (2023). Evaluating Therapies to Prevent Future Stroke in Patients with Patent Foramen Ovale–Related Strokes — The SCOPE Study. Patient-Centered Outcomes Research Institute (PCORI). https://doi.org/10.25302/04.2023.RS.SCOPE2019001

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