Many transgender women pursue medical transition with hormone therapy to help align their bodies with their female gender identity. Findings from this PCORI-funded study, which showed increased cardiovascular risks from estrogen use in transgender women, may help transgender women and their clinicians plan for ongoing health care.

The study found that incidences of venous thromboembolism (VTE) and ischemic stroke (IS) were higher in transgender women receiving estrogen than in cisgender men and women. The difference in risk increased over time. After eight years, the study found 17 excess cases of VTE per 1,000 transgender women compared with cisgender men and 14 excess cases of VTE per 1,000 transgender women compared with cisgender women. Transgender women had higher rates of myocardial infarction than cisgender women; these rates were similar to those observed in cisgender men.


Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
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