The objective of this study was (1) To develop new clinical trial designs, called adaptive enrichment designs, that can determine which patients can benefit from a new medical treatment; (2) To evaluate the new designs using simulations of trials involving treatments for HIV, stroke, and heart failure; and (3) To develop free, user-friendly software implementing these designs.
Project page: New Methods and Software for Designing Adaptive Clinical Trials of New Medical Treatments
Principal Investigator: Michael Rosenblum, PhD
Organization: Johns Hopkins Bloomberg School of Public Health
Original project title: Innovative Randomized Trial Designs to Generate Stronger Evidence about Subpopulation Benefits and Harms
HSRProj ID: 20143600
To cite this document, please use: Rosenblum M, Steingrimsson JA, Betz J. (2019). New Methods and Software for Designing Adaptive Clinical Trials of New Medical Treatments. Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). https://doi.org/10.25302/10.2019.ME.130603198
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