The objective of this study was (1) To develop new clinical trial designs, called adaptive enrichment designs, that can determine which patients can benefit from a new medical treatment; (2) To evaluate the new designs using simulations of trials involving treatments for HIV, stroke, and heart failure; and (3) To develop free, user-friendly software implementing these designs.

Project page: New Methods and Software for Designing Adaptive Clinical Trials of New Medical Treatments
Principal Investigator: Michael Rosenblum, PhD
Organization: Johns Hopkins Bloomberg School of Public Health
Original project title: Innovative Randomized Trial Designs to Generate Stronger Evidence about Subpopulation Benefits and Harms
HSRProj ID: 20143600

To cite this document, please use: Rosenblum M, Steingrimsson JA, Betz J. (2019). New Methods and Software for Designing Adaptive Clinical Trials of New Medical Treatments. Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). https://doi.org/10.25302/10.2019.ME.130603198

Tags

What's Happening at PCORI?

The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

Subscribe to PCORI Emails

Image

Hand pointing to email icon