Migraine is a common condition that is disabling for many Americans. Although pharmacologic therapies for migraine prevention exist, nonpharmacologic therapies are an important alternative. In this Topic Brief, the authors identified 164 randomized controlled trials, 27 of which were not summarized by relevant systematic reviews. They concluded that a substantive evidence base for nonpharmacologic migraine prevention therapies exists and that nonpharmacologic interventions remain an important alternative to pharmacotherapy for patients.

About these Topic Briefs

Topic briefs like this one identify and categorize the existing effectiveness and comparative effectiveness literature on a medical issue. Using this information, PCORI evaluates the state of the research literature to determine if the current research supports development of a PCORI research product such as a systematic review or a primary research study. The reviews summarize the quality and quantity of research studies. View other topic briefs


Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
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