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Cover of April 1 issue of the CDC's Morbidity and Mortality Weekly Report
Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination — PCORnet, United States, January 2021–January 2022


Covid-19 vaccination record card with syringe and vial

Results of a study appearing in the April 1 issue of the CDC's Morbidity and Mortality Weekly Report will enable a better understanding about the comparative risks of heart complications following COVID-19 infection and vaccination.

The studypowered by data accessed through PCORnet®, the National Patient-Centered Clinical Research Network, funded by PCORIis the largest to date in the U.S. to explore the risk of heart complications after infection and vaccination, and it covered a wide range of ages, from age five into adulthood.

Looking at electronic health record data from more than four million children and adults who received mRNA COVID-19 vaccines and more than 800,000 patients who tested positive for COVID-19, researchers found that the incidence of myocarditis or pericarditis was significantly higher among adolescents and young adults who tested positive for COVID-19 compared with same-aged individuals who received a vaccine.

The study is the latest example of how PCORnet is facilitating robust COVID-19 research. Other recently published results powered by PCORnet include findings regarding long COVID and disparities in treatment.

According to Deepika Thacker, MD, a pediatric cardiologist with the Nemours Children’s Health System, and a study co-author, "This study provides critical information to parents, clinicians, and policymakers. Much of the information about cardiac complications has only mentioned vaccines. There is a real risk after COVID-19 as well, and these risks need to be discussed together."

Read the Report

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