Research Results

Study: Pulse Oximeters Shown Not to Improve Outcomes for Patients with COVID-19 Recovering at Home

Patients with COVID-19 who were remotely monitored at home using a text-message-based program — known as COVID Watch — did not experience better outcomes if they used a pulse oximeter, according to research findings published in the New England Journal of Medicine.

Supported in part by PCORI funding, the study — led by Mucio Delgado, MD, MS, at the University of Pennsylvania Perelman School of Medicine — compared patients who received standard care as part of the COVID Watch program to patients in the same program who were given a pulse oximeter to monitor their oxygen levels. Researchers found that adding the pulse oximeter did not save more lives or keep more people out of the hospital.

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Study: COVID-19 Healthcare Workers Experienced Rates of Moral Injury Similar to Combat Veterans

A PCORI-funded research registry of more than 55,000 healthcare workers and their families has powered a study that provides important insights into the psyche of COVID-19 healthcare workers during the pandemic.

Results appearing in the Journal of General Internal Medicine show that COVID-19 healthcare workers experienced high rates of potential moral injury that are comparable to rates among combat veterans. Moral injuries are defined as actions that conflict with values and beliefs, causing psychological harm.

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Heart Complication Risk Higher After COVID-19 Infection Than Vaccination, Study Finds

Looking at electronic health record data from more than four million children and adults who received mRNA COVID-19 vaccines and more than 800,000 patients who tested positive for COVID-19, researchers found that the incidence of myocarditis or pericarditis was significantly higher among adolescents and young adults who tested positive for COVID-19 compared with same-aged individuals who received a vaccine.

These results will enable a better understanding about the comparative risks of heart complications following COVID-19 infection and vaccination. The US Centers for Disease Control and Prevention-led study is the latest example of how PCORnet®, the National Patient-Centered Clinical Research Network—funded by PCORI—is facilitating robust COVID-19 research.

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Study Using PCORnet® Suggests Disparities in Receipt of COVID-19 Medications

Underscoring the health inequities that have characterized the COVID-19 pandemic, an analysis of health data accessed via a PCORI-funded network suggests that monoclonal antibodies, medications highly effective at lessening the severity of COVID-19, are underused among individuals who identify as Black, Asian, or Hispanic. This apparent underuse occurred even though these groups are experiencing higher rates of infection, hospitalization, and death.

The US Centers for Disease Control and Prevention-led study analyzed patient data from 41 healthcare systems participating in PCORnet®, the National Patient-Centered Clinical Research Network, funded by PCORI to conduct research more efficiently.

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Changes to Telehealth Policy, Delivery, and Outcomes in Response to COVID-19

During the COVID-19 pandemic, there has been a rapid shift toward virtual visits and digital tools to monitor and help patients manage their health care. PCORI solicited a landscape review to summarize how reimbursement, regulatory, and delivery systems have changed for telehealth during the coronavirus pandemic. The goal was to use this information, in combination with conversations with key stakeholders, to better understand how changes in the delivery system during COVID-19 might alter PCORI’s strategic focus on future investment in telehealth research. This report provides a rich summary of changes under the pandemic and highlights some areas in telehealth where additional research may be valuable.

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Database Identifies Emerging Technologies, Innovations

PCORI's Health Care Horizon Scanning System identifies and monitors new and emerging healthcare technologies and innovations with high potential to change the current standard of care. This systematic process informs PCORI’s investments in patient-centered outcomes research.

PCORI’s Horizon Scanning Database offers healthcare decision makers findings about advancements in six key areas of interest: Alzheimer’s disease and other dementias, cancer, cardiovascular diseases, COVID-19, mental and behavioral health, and rare diseases. This database can be used by patients, care partners, and others to track advancements in care options.

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PCORnet Facilitates New Research on Drugs' Effectiveness for COVID-19

ACTIV-6 — a new clinical trial platform unveiled by the National Institutes of Health — will use PCORnet®, the National Patient-Centered Clinical Research Network, to help determine if some prescription and over-the-counter medications can effectively treat COVID-19 in non-hospitalized patients. While some drugs approved for other conditions have been studied to treat mild to moderate cases of COVID-19, ACTIV-6 aims to provide definitive evidence for patients and clinicians seeking to manage the disease and avoid hospitalization.

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PCORI-Funded Research Studies and Engagement Awards

Closed PCORI Funding Announcements

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The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

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