Kidney Disease

Topic Spotlight


An estimated 37 million people in the United States are affected by chronic kidney disease. (Centers for Disease Control and Prevention)


Approximately 33% (1 in 3) of adults with diabetes -- and 1 in 5 adults with high blood pressure -- may have chronic kidney disease. (Centers for Disease Control and Prevention)


PCORI has funded 24 comparative clinical effective research studies that aim to help patients and those who care for them make better-informed decisions about their treatment options for kidney disease. (As of February 2022)

Evidence for Decisions from PCORI-Funded Studies

Evidence Updates: Treating Depression in Patients with Kidney Failure Receiving Dialysis

More patients with kidney failure undergoing long-term hemodialysis who also had depression reported modest improvements in their depressive symptoms with the drug sertraline than patients receiving cognitive behavioral therapy, PCORI-funded researchers report in the Annals of Internal Medicine. However, patients who opted for the daily medication experienced greater adverse events, such as nausea and dizziness.

A pair of Evidence Updates is now available to help support conversations between patients and/or their caregivers and clinicians about treating depression while receiving maintenance hemodialysis.

View the Evidence Updates

Kidney Disease Study Spotlights