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Kidney Disease

Topic Spotlight

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An estimated 37 million people in the United States are affected by chronic kidney disease. (Centers for Disease Control and Prevention)

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Approximately 33% (1 in 3) of adults with diabetes -- and 1 in 5 adults with high blood pressure -- may have chronic kidney disease. (Centers for Disease Control and Prevention)

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PCORI has funded 24 comparative clinical effective research studies that aim to help patients and those who care for them make better-informed decisions about their treatment options for kidney disease. (As of February 2022)

Evidence for Decisions from PCORI-Funded Studies


Evidence Updates: Treating Depression in Patients with Kidney Failure Receiving Dialysis

More patients with kidney failure undergoing long-term hemodialysis who also had depression reported modest improvements in their depressive symptoms with the drug sertraline than patients receiving cognitive behavioral therapy, PCORI-funded researchers report in the Annals of Internal Medicine. However, patients who opted for the daily medication experienced greater adverse events, such as nausea and dizziness.

A pair of Evidence Updates is now available to help support conversations between patients and/or their caregivers and clinicians about treating depression while receiving maintenance hemodialysis.

View the Evidence Updates

Kidney Disease Study Spotlights