Topic Spotlight

Multiple Sclerosis

PCORI Answers Critical Questions

Evidence gaps can make it difficult to know which multiple sclerosis treatment will work best given a patient’s needs. PCORI funds studies that seek to help patients, clinicians and others answer various questions they might have about treatment options, such as:

Patient: I’m over 55 and my MS has been stable for years. Should I stay on my disease-modifying drug or consider a different treatment?

Clinician: In my rural community, would telerehabilitation be as effective as in-clinic rehabilitation? Would it provide a good option for patients without easy access to MS specialty centers?

Patient: Which of the available medications work best to treat my fatigue?

Multiple Sclerosis Study Spotlights

Comparing Treatments That Patients Take for Many Years

This study is using information from a Swedish database of patients with MS and from patients in Southern California with MS to look at how effective and safe rituximab is relative to other medicines used to treat MS over a period of up to nine years.

People Involved in MS Research

Hear about several comparative clinical effectiveness research studies that aim to help patients and those who care for them make better-informed decisions about their options for treating MS.

Clinic versus Home-Based MS Therapy

Clinics that provide exercise, yoga, and other nondrug therapies are scarce in rural and low-income areas. This study compares the benefits of an exercise program when patients receive it in a clinic versus at home via internet or telephone.

Multiple Sclerosis Portfolio Snapshots

Multiple Sclerosis portfolio - most studied populations of interest
Older adults 3
Racial/ethnic minorities 1
Urban 2
Low socioeconomic status 1
Individuals with disabilities 4
Women 3
As of September 2017
57% of PCORI's 12 funded studies related to multiple sclerosis focus on comparative effectiveness of drug therapies. As of September 2017