Topic Spotlight

Older Adults'  Health

PCORI Answers Critical Questions

Evidence gaps can make it difficult to know which approaches to care will work best given a patient’s specific needs. PCORI funds studies that seek to help older adults and those who care for them answer questions they face when making healthcare choices, such as:

Caregiver: My mom is getting a little frail as she ages. I’ve heard exercise can improve older people’s walking and avoid falls, which would enable her to continue living in her own home. Are some types of exercise classes for older people better than others at accomplishing this?

Clinician: Managing asthma can be hard for patients who have complex challenges such as multiple chronic conditions and functional declines, which are common among older adults. Which evidence-based approaches to self-management can best help older adults, especially African-American and Hispanic individuals, keep their asthma under control?

Patient: Some people say I ought to get my recently diagnosed ductal carcinoma in situ, or DCIS, treated right away. Others say I should just wait and closely monitor it, especially given my age. What’s the right thing to do?


Open Targeted PCORI Funding Announcements (PFAs)

Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum -- Cycle 3 2021

With the different phases of the aging continuum in mind, PCORI is seeking proposals that aim to define ways to achieve one or more of the following four goals: Maintaining function and independence; Facilitating chronic disease management; Supporting individuals with significant functional impairment; Reducing caregiving burden and improving quality of life. PCORI is offering up to $5 million in total direct costs per study. Letters of Intent are due Tuesday, October 5, by 5:00 p.m. ET. Catch up on a public forum about this PFA.

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Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures -- Cycle 3 2021

PCORI is seeking proposals that aim answer this question: What is the comparative effectiveness of multimodal treatment interventions (i.e., combination of pharmacologic and/or non-pharmacologic) on patient-centered outcomes in people with osteoporosis and a history of fractures? PCORI is offering up to $10 million in total direct costs per study. Letters of Intent are due Tuesday, October 5, by 5:00 p.m. ET.

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Study Results that Support Better-Informed Decisions

Comparing Surgical Treatments for Cervical Spondylotic Myelopathy

Cervical spondylotic myelopathy, or CSM, occurs when the spinal cord becomes compressed as people age and is the most common cause of spinal cord dysfunction worldwide. A PCORI-funded study -- conducted by a team at the Lahey Clinic in Massachusetts -- examined patient-reported outcomes one year after surgery among patients who received any of the three common surgical treatments for CSM. As reported in JAMA, compared with the other two types of surgery, patients with dorsal laminoplasty had better physical function and fewer problems from surgery. They were also less likely to report using opioids for pain, having imaging tests, and having ongoing physical therapy.

Comparing Ways to Address Worry among Older Adults

As reported in Depression and Anxiety, a research team at Wake Forest University found that cognitive behavioral therapy (CBT) and yoga were both effective at reducing worry and anxiety in older adults, while CBT improved sleep more than yoga. In the study, the team -- led by Gretchen Brenes, PhD -- assigned half of the older adults to CBT or yoga by chance; the other half chose between CBT and yoga. These results held regardless of whether the participants chose their treatment or were assigned treatment at random.

Acknowledging Age-Related Issues Improves Communication

Age-related challenges—including memory loss, limited caregiver availability, or chronic conditions—can affect how older adults respond to treatment for cancer, but physicians sometimes aren’t aware of them. The COACH Study wanted to see if a report about issues related to a patient’s age would improve care-planning communication among the patient, caregiver, and doctor. As reported in JAMA Oncology, compared with patients without a report, patients who had one were engaged in and more satisfied with conversations with their physician.

Trial Assessed Personalized Approach to Reducing Older Adults’ Risks for Fall-Related Injuries

In a paper in the New England Journal of Medicine, the PCORI- and National Institutes of Health-funded STRIDE Study reported that having nurses tailor and administer fall-prevention plans for older adults at high risk resulted in about an 8 percent to 10 percent reduction in serious fall injuries, but this effect was not statistically significant. The paper discusses potential barriers to care and other factors that could account for why a more significant reduction in serious fall injuries was not seen when risk-reduction strategies shown to be effective in previous studies were deployed this way in real-world circumstances and settings.

Achieving Patient-Centered Care Transitions

The first phase of this PCORI-funded study asked older adult patients and family caregivers which outcomes of transitions in care between different settings matter most to them, a question that previous research has not thoroughly explored. The study identified three outcomes: feeling prepared to implement their care plans, accountability from care settings, and feeling their healthcare providers care about them. These early findings are part of a larger, ongoing study.

Direct Oral Anticoagulants versus Warfarin for Stroke Treatment

The PCORI-funded PROSPER study compared outcomes of older adults who have atrial fibrillation and have had a stroke. In a new paper published in JAMA Neurology, the research team reports that patients who were prescribed direct oral anticoagulants when discharged from the hospital following a stroke had relatively better outcomes—including more days at home and fewer adverse events—than patients prescribed the blood thinner warfarin. This reinforces findings from prior research on the subject.

Spotlights on Ongoing Studies and Projects

Teaching Older Adults and Their Caregivers about PCOR

This project, supported by a PCORI Engagement Award, created a network of senior patients and family caregivers focused on clinical areas important to older Americans. The project team teaches these stakeholders about patient-centered outcomes research (PCOR) and how to engage with researchers so that senior patients and their caregivers can participate in PCOR projects.

Preventing Fall-Related Injuries in Older Adults

Every year, roughly one in three adults over age 65 falls. These falls can lead to serious injury, disability, and even death. This project, a joint initiative with the NIH National Institute on Aging, is comparing two approaches that aim to reduce falls among older adults who live at home alone. In one arm of the study, patients receive general information about preventing falls, and in the other arm, patients work with a nurse who is a fall-care manager to develop and follow a plan to prevent falls, taking into consideration the individual patient’s risk factors.

Improving Outcomes after Hip Fractures among Older Adults

Hip fractures send more than 300,000 older adults to hospitals each year, and the vast majority of patients must undergo surgery that requires anesthesia. Previous research suggests that spinal anesthesia may help patients get better faster and with less pain than general anesthesia. This study is comparing short- and long-term patient outcomes of general versus localized anesthesia for hip fracture surgery.

NIH Study Targeting Older Adults Will Leverage PCORnet Data Resource

Older Male Sitting By Side of Bed Looking Sad With Pills In His Hand.

A $90 million National Institutes of Health-funded study assessing statins’ abilities to prevent dementia and other disabilities in older adults will take advantage of PCORnet®, the National Patient-Centered Clinical Research Network. This exciting study is the strongest demonstration yet that PCORnet has evolved into a valuable national resource that will help research get done faster and more efficiently.

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Older Adults' Health Portfolio Snapshots

The most studied populations of projects that PCORI funds for older adults' health:
Racial/ethnic minorities - 13
Individuals with multiple chronic conditions - 12
Low income - 12
Women - 7
Low health literacy - 5
Individuals with disabilities
The most studied conditions of projects that PCORI funds for older adults' health:
Multiple chronic conditions - 9
Cancer - 8
Mental/behavioral health - 7
Neurological disorders - 6
Cardiovascular diseases - 5
Functional limitations and disabil